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. 2021 Jan 8;70(4):932–943. doi: 10.2337/db20-0937

Figure 2.

Figure 2

Significant effect of GADA, IA–2A, and ZnT8A levels on the probability of detecting C-peptide. A, C, and E: Dashed lines show the fitted predicted probability of C-peptide detection (y-axis) according to type 1 diabetes duration. GRS is set to the median. B, D, and F: Difference in predicted probability between the 80th and 20th autoantibody titer percentiles was plotted according to disease duration. The vertical dotted line marks the duration at which the difference in predicted probability between the 80th and 20th autoantibody percentiles was the greatest. A: Fitted predicted probability of C-peptide detection for subjects at the 80th GADA titer percentile (dark-red dashed line) and at the 20th GADA titer percentile (light-red dashed line). B: Difference in predicted probability between the 80th and 20th GADA titer percentiles according to disease duration. The vertical dotted line marks the duration at which the difference in predicted probability between the 80th and 20th GADA percentiles is the greatest (2.1 years’ duration). C: Fitted predicted probability of C-peptide detection for subjects at the 80th IA–2A titer percentile (dark-blue dashed line) and at the 20th IA–2A titer percentile (light-blue dashed line). D: Difference in predicted probability between the 80th and 20th IA–2A titer percentiles according to disease duration. The vertical dotted line marks the duration at which the difference in predicted probability between the 80th and 20th IA–2A titer percentiles is the greatest (0 years’ duration). E: Fitted predicted probability of C-peptide detection for subjects at the 80th ZnT8A titer percentile (dark-green dashed line) and at the 20th ZnT8A titer percentile (light-green dashed line). F: Difference in predicted probability between the 80th and 20th ZnT8A titer percentiles according to disease duration. The vertical dotted line marks the duration at which the difference in predicted probability between the 80th and 20th ZnT8A titer percentiles is the greatest (0 years’ duration). %tile, percentile.