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. 2021 Jan 8;70(4):932–943. doi: 10.2337/db20-0937

Figure 3.

Figure 3

Interaction effect of ZnT8A titer, GRS, and type 1 diabetes duration on the probability of detecting C-peptide. For illustration of the effect of GRS on the association between ZnT8A titer and detectable C-peptide, the predicted probability of C-peptide detection was plotted with GRS set to the 20th percentile (A and B) and the 80th percentile (C and D) according to disease duration. A and C: Dashed lines show the fitted predicted probability of C-peptide detection (y-axis) at the 80th ZnT8A titer percentile (dark-green dashed line) and at the 20th ZnT8A titer percentile (light-green dashed line). B and D: Difference in predicted probability of C-peptide detection between the 80th and 20th ZnT8A titer percentiles according to disease duration. The vertical dotted line marks the duration at which the difference in predicted probability between the 80th and 20th ZnT8A titer percentiles is the greatest. A: Interaction effect between ZnT8A and type 1 diabetes duration when GRS is set to the 20th percentile. At the 20th GRS percentile, the probability of C-peptide detection declined more rapidly when ZnT8A titer was high (dark-green dashed line) compared with when ZnT8A titer was low (light-green dashed line). B: At the 20th GRS percentile, the difference in predicted probability between the 80th and 20th ZnT8A titer percentiles was the greatest at 6.6 years’ duration. C: Interaction effect between ZnT8A and type 1 diabetes duration when GRS is set to the 80th percentile. At the 80th GRS percentile, the probability of C-peptide detection declined with increased disease duration, regardless of ZnT8A titer. D: At the 80th GRS percentile, the difference in predicted probability between the 80th and 20th ZnT8A titer percentiles was the greatest at disease onset (i.e., 0 years). %tile, percentile.