Table 3.
Genome-wide significant findings for subjects with youth-onset T2D vs. adult control subjects with and without adjustment for BMI
| SNP | Chromosome | Position | Gene | Type | Effect allele | Non-effect allele | OR | P value | BMI-adjusted OR | BMI-adjusted P value |
|---|---|---|---|---|---|---|---|---|---|---|
| rs7903146 | 10 | 114758349 | TCF7L2 | Intron | T | C | 1.52 | 3.5 × 10−11 | 1.59 | 2.0 × 10−11 |
| rs72982988 | 18 | 57802714 | MC4R | Intron | A | G | 1.55 | 2.2 × 10−9 | 1.45 | 2.9 × 10−6 |
| rs200893788 | 10 | 12283161 | CDC123 | Intron | T | TAGTA | 1.35 | 1.2 × 10−7 | 1.40 | 7.6 × 10−8 |
| rs2237892 | 11 | 2839751 | KCNQ1 | Intron | C | T | 1.61 | 3.9 × 10−6 | 1.70 | 5.4 × 10−6 |
| rs10992863 | 9 | 185537636 | PHF2 | Insertion | G | A | 1.33 | 4.0 × 10−6 | 1.25 | 1.2 × 10−4 |
| rs937589119 | 3 | 96445803 | IGF2BP2 | Intergenic | GT | G | 1.32 | 4.7 × 10−5 | 1.37 | 2.5 × 10−5 |
| rs113748381 | 17 | 6953155 | SLC16A11 | Intergenic | A | G | 0.99 | 4.1 × 10−3 | 0.92 | 3.6 × 10−2 |
Association tests for 898 case subjects with youth-onset T2D in whom BMI information was available were adjusted for sex and genetic relationship matrix and compared before and after BMI z-score adjustment.