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. 2021 Mar 18;81(6):1246–1259.e8. doi: 10.1016/j.molcel.2021.01.005

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© 2021 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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The Integrator cleavage module and HCC

(A and B) Front view of the structure of the nuclease heterodimers (INTS9/11 and CPSF73/100), showing overall good agreement between the two structures and similar positions of the INTS9^NAD and CPSF100^PIM domains (PDB: 6V4X).

(C–E) Close up and superposition of the CPSF100- and INTS9-specific inserts. The two independent chains of INTS9^NAD are colored yellow (40–86) and orange (148–177).

(F) Schematic depiction of the differences in positioning of INTS4 and Symplekin in their respective complexes.

(G) Side view of the INTS4/9/11 complex.

(H) Side view of the CPSF73/100/Symplekin complex, shown in the same orientation as INTS4/INTS9/INTS11 in (D), highlighting different positions of INTS4^NTD and Symplekin^NTD.