TABLE IV.

Indications and contraindications for an aspirin desensitization and aspirin therapy in patients with AERD

Indications

Persistent sinonasal and asthma symptoms in a patient with AERD despite conventional medical and surgical therapy

Contraindications

Poorly controlled asthma

Significant nasal polyp burden at time of desensitization

Pregnancy

History of eosinophilic esophagitis

History of gastric and/or peptic ulcer disease

History of a bleeding disorder or coagulopathy

History of medication nonadherence

Relative contraindication

History of anaphylaxis to aspirin or other NSAID*

^*Patients with a history of anaphylaxis to aspirin or other NSAID may undergo an aspirin desensitization and aspirin therapy, but this decision merits careful discussion with the patient and physician.