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. Author manuscript; available in PMC: 2021 Mar 20.
Published in final edited form as: Clin Cancer Res. 2020 Jul 1;26(18):5007–5018. doi: 10.1158/1078-0432.CCR-18-1359

Figure 2:

Figure 2:

(A) Gross image of pancreas (blue dotted line) and PDAC tumor (yellow dotted line) 14 days after orthotopic injection. (B) Hematoxylin and eosin (H&E) staining of the tumor and surrounding pancreas. Histologic features are labeled with arrows. (C) Sirius Red staining of the tumor and surrounding pancreas. Desmoplastic reaction at the tumor’s infiltrating edge is indicated by intense red stain (increased collagen density). (D) Immunofluorescent staining of αSMA in tumor and surrounding pancreas. (E) Collagen proportional area (CPA) of tumor and surrounding pancreatic tissue. T = tumor; P = pancreas. * p < 0.05; ** p < 0.01.