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. 2021 Mar 19;18:13. doi: 10.1186/s12989-021-00405-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Cytotoxicity of Nano-Ni and Nano-TiO₂ in HaCaT cells. HaCaT cells were seeded into 96-well plates and treated with different concentrations of Nano-Ni or Nano-TiO₂ for 24 h. Cells without treatment were used as control. The cytotoxicity was determined by MTS assay (a) and SRB assay (b). Data represent mean ± SE (n = 6). * Significant difference as compared with the control group, p < 0.05; ^# Significant difference as compared with the same dose of Nano-TiO₂-treated group, p < 0.05