Fig. 6.
PGR-AOE_DEG and PGR-BOE_DEG gene signatures in human myometrial tissues. (A and B) t-scores of the denoted gene signatures, as surrogates of PGR-A (A) and PGR-B (B) molecular activities, in nonpregnant and term pregnant myometrial specimens (GSE137551). *P < 0.05 by two-tailed unpaired t test with Welch’s correction. Error bars denote SEM. (C–E) Percentages of enriched myometrial remodeling-related molecular processes in association with PGR-A– and PGR-B–dependent genome regulation. Differentially expressed genes between term pregnant and nonpregnant human myometrium (GSE137551) were used to identify enriched myometrial remodeling biological processes.