Table 1.
Molecular functions of PGR isoform targets by IPA
| PGR-AOE_DEG | PGR-BOE_DEG | |||
| Activation z-score | P value of overlap | Activation z-score | P value of overlap | |
| Function/disease | ||||
| Recruitment of leukocytes | 2.0 | 1.18 × 10−7 | −0.35 | 5.00 × 10−9 |
| Glucose metabolism disorder | 1.60 | 2.02 × 10−18 | −0.94 | 6.63 × 10−13 |
| Neovascularization | −0.12 | 2.73 × 10−6 | 1.83 | 5.78 × 10−7 |
| Growth of connective tissue | −0.92 | 2.66 × 10−6 | 1.55 | 7.10 × 10−8 |
| Molecular activities | ||||
| IL1β | 1.99 | 2.27 × 10−13 | 0.54 | 2.45 × 10−12 |
| TNF | 2.34 | 6.54 × 10−14 | 0.29 | 5.57 × 10−10 |
| NFkB (complex) | 2.32 | 1.26 × 10−7 | 0.54 | 1.21 × 10−7 |
| Glucocorticoid | −1.01 | 4.23 × 10−4 | 1.38 | 8.56 × 10−4 |
| Losartan potassium | — | — | 0.99 | 1.60 × 10−5 |
| Y-27632 | −1 | 1.11 × 10−2 | 0.80 | 9.80 × 10−3 |
| D-glucose | 2.21 | 1.40 × 10−9 | 0.06 | 4.37 × 10−6 |
| LIPE | — | 3.90 × 10−5 | 2.41 | 2.95 × 10−7 |
IL1β: interleukin 1 beta; TNF: tumor necrosis factor; NFkB: nuclear factor kappa-light-chain-enhancer of activated B cells; LIPE: lipase E.