Fig. 2.
Type I IFN response gene signature in CAV1-deficient primary human PAECs. (A) Differentially expressed genes within four top biofunctions are displayed as heat maps: antiviral response (n = 30 genes, P = 1.05 × 10−16); cell movement (n = 114 genes, P = 2.01 × 10−12); systemic autoimmunity (n = 79 genes, P = 2.39 × 10−12); and endothelial cell proliferation (n = 28 genes, P = 3.11 × 10−9). Orange signifies expression above and blue below the mean within each row. For full annotations, see Dataset S1. (B) Up-regulated transcripts in CAV1-silenced PAECs (FDR ≤ 10% and FC ≥ 1.2; n = 227) were used to create a functionally organized network of immune related pathways and functions in ClueGO (v2.5.4) based on GO (GO_ImmuneSystemProcesses) and Reactome pathway annotation terms. Node size corresponds to the enrichment significance of the terms and central nodes are denoted by colored text. Pathway threshold set at P ≤ 0.01.