Fig. 4.

Activation of STAT/AKT signaling and CXCL10 production in Cav1^−/− mice replicates CAV1 loss in primary human PAECs. (A) Total and phosphorylated (activated) STAT1 and (B) total and phosphorylated (activated) AKT were significantly increased in Cav1-null mice compared to wild-type controls. Densitometric quantification of protein normalized to β-actin presented relative to wild-type controls as mean ± SE, along with representative Western blots. (C) Circulating CXCL10 measured by ELISA (mean ± SE) was significantly increased in Cav1^−/− mice compared to wild-type controls. *P < 0.05, **P < 0.01, ***P < 0.001.