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. 2021 Mar 8;118(11):e1907653118. doi: 10.1073/pnas.1907653118

Fig. 2.

Fig. 2.

CD47 blockade-treated mice survive the cerebral phase of Pb-A infection. (A) Pb-A infection survival curves of PBS and anti-CD47–treated (MIAP410) mice. Cerebral phase of infection is 6 to 10 d postinfection. (B) Percent parasitemia over the course of Pb-A infection in C57BL/6 mice treated with PBS or anti-CD47 (MIAP410) plotted as mean ± SEM (n = 5). (C) Pb-A infection survival curves of PBS and anti-CD47 treated (MIAP410) macrophage-depleted mice. Depletion was achieved by established methods using anti-CSF1R for 2 wk prior to infection and was continued throughout the experiment. (D) Percent parasitemia over the course of Pb-A infection in macrophage-depleted C57BL/6 mice treated with PBS or anti-CD47 (MIAP410) plotted as mean ± SEM (n = 5).