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. 2021 Mar 8;118(11):e1907653118. doi: 10.1073/pnas.1907653118

Fig. 4.

Fig. 4.

CD47 blockade reduces pathologic features of ECM. (A) H&E staining of brain tissue of PBS treated C57BL/6 mice on day 6 postinfection with Pb-A taken at 10× and (B) 20×, compared to (C) anti-CD47 treated mice taken at 10× and (D) 20×. Red box represents field of view for 20× magnification. (E) Representative images of brains following Evans blue permeability assay, to measure blood–brain barrier integrity, of C57BL/6 mice on day 6 postinfection treated with PBS, anti-CD47 (MIAP410) compared to an uninfected control. (F) Quantification of blood–brain barrier permeability represented as fold-change absorbance (OD620) over uninfected controls. (G) FACS quantification of CD8+ T cells located within the perfused brain tissue of C57BL/6 mice on day 6 postinfection with Pb-A from PBS or anti-CD47 (MIAP410)-treated mice. (H) Percent of Granzyme B+ CD8+ T cells. (I) Percent of IFN-γ+ CD8+ T cells. (n = 5) (*P < 0.05).