FIGURE 1.
MG53 is present in aqueous humor and tears; genetic ablation of MG53 leads to compromised corneal wound healing. (A) MG53 is a member of TRIM family proteins with RING, B-box, Coiled-coil, and SPRY domains. Endogenous MG53 can be detected in canine aqueous humor (B) and human tear (pointed by the arrow) (C) samples. Bands above 55 kDa in (C) are nonspecific protein recognized by the antibody. (D) After alkaline-induced corneal injury, mg53-/- cornea developed higher level of opacity and vascular invasion as compared to those in wild-type cornea.