Figure 4. Combination cabozantinib and anti-Interleukin-1β modulate intratumoral cytokines.

A) Z-scores of differentially expressed genes from CD45+ intratumoral immune cells (n=3 mice/group). B) Mesoscale quantification of intratumoral cell lysates of select cytokines using U-Plex panel. (n=5 mice/group). Error bars are mean +/− standard error of mean. Data for vehicle and anti-IL-1β are from the same sorted immune cells described in figure 2. *P< 0.05, ** P < 0.005