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rhERAPs stimulation favors monocyte activation and differentiation in specific subsets. PBMCs isolated from 15 HCs were stimulated with 100 ng/ml of rhERAP1, rhERAP2, or rhERAP1+rhERAP2 for 24 h. The percentage of total CD14+ CD16+), classical (CD14++CD16−), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++) monocytes expressing the activation markers DRII and CCR7 was assessed by flow cytometry. Mean values and SEM are shown. *p < 0.05, **p < 0.01.
