Table III. Logistic regression models evaluating 28-d survival.
| Univariate |
Multivariate (Model A)a |
Multivariate (Model B)b |
||||
|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| Gender, males versus females | 0.67 | 0.27–1.79 | — | — | — | — |
| Oxygen support, CPAP versus intubation | 0.46 | 0.17–1.30 | — | — | — | — |
| Age, per 1 y more | 0.87 | 0.82–0.93 | 0.88 | 0.81–0.95 | — | — |
| P/F, per 10 mm Hg higher | 1.21 | 1.08–1.36 | 1.20 | 1.05–1.37 | — | — |
| CCI, per 1 point higher | 0.46 | 0.32–0.64 | 0.55 | 0.31–0.98 | — | — |
| Hypertension | 0.37 | 0.17–0.82 | 0.98 | 0.32–3.16 | — | — |
| Ischemic heart disease | 0.35 | 0.13–0.95 | 0.67 | 1.16–2.79 | — | — |
| COPD | 1.042 | 0.24–4.60 | — | — | — | — |
| Diabetes mellitus | 0.94 | 0.54–1.73 | — | — | — | — |
| Obesity/overweight (BMI >25 kg/m2) | 2.13 | 0.96–4.71 | — | — | — | — |
| Anakinra use | 3.20 | 1.47–7.17 | 2.46 | 0.87–7.00 | 5.61 | 1.75–10.01 |
| CRP, per mg/dl higher | 0.97 | 0.93–1.02 | — | — | 0.99 | 0.94–1.04 |
| D-dimer, per 100 ng/ml higher | 0.98 | 0.96–1.01 | — | — | 0.99 | 0.97–1.01 |
| Lymphocytes, per 1000 cells/mm3 higher | 0.48 | 0.18–1.29 | — | — | — | — |
| Ferritin, per 100 ng/ml higher | 1.03 | 0.98–1-08 | — | — | — | — |
| Symptom duration before hospitalization, per 1 d higher | 1.05 | 0.96–1.14 | — | — | — | — |
a
Model A included all correlates that were significantly associated with survival in the univariate model.
b
Model B included all the correlates that were differently distributed at baseline in the two study groups (i.e., CRP and d-dimer).
BMI, body mass index; CCI, Charlson comorbidity index; COPD, chronic obstructive pulmonary disease; P/F, partial pressure of oxygen in arterial blood to fractional concentration of oxygen.