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. 2021 Mar 9;13(5):1184. doi: 10.3390/cancers13051184

Figure 7.

Figure 7

Integrin α10 antibody treatment reduces Ki67 and increases cleaved caspase-3 in GB tumors. (A) Representative immunohistochemical images of expression of Ki67 in the xenograft tumors from mice treated with control antibodies (Th301 and IgG2a) or integrin α10 antibodies (Th101 and mAbα10). Scale bars represent 10 µm. (B) The percentage of Ki67-positive cells in the tumors was reduced in Th101- and mAbα10-treated mice (n = 4 and n = 5, respectively). (C) Representative immunohistochemical images of cleaved caspase-3 expressions in xenograft tumors from mice treated with control antibodies (Th301 and IgG2a) or integrin α10 antibodies (Th101 and mAbα10). The scale bar represents 100 μm. (D) The percentage of cleaved caspase-3-positive cell area in the tumors was significantly increased in Th101- and mAbα10-treated mice compared to control mice. Results are presented as the mean ± SE from six tumor samples per group. Unpaired two-tailed Student t-test was applied. Four levels of significance were used for a 95% confidence interval, where * p < 0.05; *** p < 0.001; and ns: no significant.