Table 3.

Results under 5CV of different feature combinations considered on RPI1807 and NPInter v2.0

Dataset	Combinations of features	ACC (%)	TPR (%)	TNR (%)	PPV (%)	F1 (%)	MCC (%)	AUC (%)
RPI1807	Sequence	92.1 ± 1.3	94.5 ± 2.7	85.1 ± 2.9	94.9 ± 0.8	94.7 ± 0.9	79.5 ± 2.9	96.2 ± 0.8
	Secondary structure	92.8 ± 1.2	96.6 ± 1.9	81.5 ± 6.6	94.0 ± 2.1	95.2 ± 0.7	80.7 ± 3.5	96.1 ± 1.1
	Tertiary structure	72.9 ± 9.6	85.7 ± 21.7	28.7 ± 28.7	82.9 ± 6.9	79.7 ± 12.7	26.9 ± 21.5	81.6 ± 8.7
	Sequence + secondary structure	93.8 ± 0.6	96.6 ± 1.2	85.5 ± 2.5	95.2 ± 0.8	95.9 ± 0.4	83.5 ± 1.5	96.5 ± 0.8
	Sequence + tertiary structure	92.6 ± 1.6	95.1 ± 2.2	85.1 ± 2.9	95.0 ± 0.9	95.0 ± 1.1	80.5 ± 3.9	96.3 ± 0.8
	Secondary structure + tertiary structure	92.4 ± 0.4	96.5 ± 1.5	80.6 ± 5.6	93.7 ± 1.6	95.0 ± 0.2	79.7 ± 1.3	96.2 ± 0.9
	All features	94.3 ± 0.2	97.4 ± 1.0	85.1 ± 1.9	95.1 ± 0.6	96.2 ± 0.2	84.7 ± 0.7	96.7 ± 0.8
NPInter v2.0	Sequence	87.7 ± 0.8	89.7 ± 1.1	85.7 ± 2.4	86.3 ± 1.9	87.9 ± 0.7	75.5 ± 1.6	94.6 ± 0.3
	Secondary structure	78.8 ± 1.4	87.5 ± 1.4	70.1 ± 2.4	74.6 ± 1.6	80.5 ± 1.2	58.5 ± 2.7	88.1 ± 1.0
	Tertiary structure	54.7 ± 3.8	68.1 ± 27.0	41.4 ± 33.6	58.7 ± 8.7	56.3 ± 10.6	10.9 ± 8.7	59.9 ± 2.7
	Sequence + secondary structure	89.1 ± 0.9	91.2 ± 1.1	86.9 ± 1.5	87.5 ± 1.3	89.3 ± 0.8	78.3 ± 1.7	95.4 ± 0.3
	Sequence + tertiary structure	88.9 ± 0.8	91.1 ± 1.1	86.8 ± 1.3	87.3 ± 1.1	89.2 ± 0.7	77.9 ± 1.5	95.2 ± 0.5
	Secondary structure + tertiary structure	83.5 ± 1.0	88.6 ± 1.5	78.5 ± 2.6	80.5 ± 1.8	84.3 ± 0.7	67.5 ± 1.9	92.0 ± 0.4
	All features	90.0 ± 0.7	92.2 ± 1.1	87.6 ± 0.9	88.2 ± 0.8	90.2 ± 0.7	80.0 ± 1.4	96.2 ± 0.3

The values in bold indicate this performance metric is the best among the three methods

The mathematical notation (±) represents standard deviation