Fig. 4.

Derivation of an RBC velocity-adjusted perfused boundary region. a Box plots showing PBR_static (D 4 to 25 µm) in healthy controls (green) and sepsis patients (red). b Scatter dot plots and simple linear regression (slope) with 95% confidence intervals of PBR_static (D 4 to 25 µm) plotted against V_RBC in feed vessels (D ≥ 10 µm). Different states at the ends of the slope lines (indicated by green/red bold letters A-D) are further explained in Fig. 6. c Box plots of PBR_dynamic, a velocity-adjusted estimate of the PBR where the V_RBC (D ≥ 10 µm) was set to 0 µm/s. RBC red blood cell, CBV capillary blood volume, D diameter, V velocity