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. 2021 Mar 19;40:107. doi: 10.1186/s13046-021-01906-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — miR-106b-5p expression is upregulated in melanoma and an independent risk factor for the survival of patients with melanoma. a The expression of miR-106b-5p was detected in 36 malignant melanoma tissues and adjacent normal tissues. b The miR-106b-5p levels was analyzed by using GEO#GSE34460 dataset. c The miR-106b-5p levels was analyzed through GEO#GSE24996 dataset. d FISH analysis of miR-106b-5p in malignant melanoma tissues and adjacent normal tissues. Scale bar, 100 μm. e The miR-106b-5p expression profile in human melanoma cell lines (A375, A2058, SK-MEL-28, SK-MEL-1) and human epidermal melanocytes (HEMa-LP). f The overall survival curves of melanoma patients with high miR-106b-5p levels and low miR-106b-5p levels. g The prognostic data of melanoma in TCGA by using OncoLnc (http://www.oncolnc.org). Data were expressed as the mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001