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. 2021 Mar 19;21:95. doi: 10.1186/s12890-021-01459-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Differential diagnosis of the five types of pleural effusion by decision-tree analysis. The combination of ADA, S-Alb, S-LDH, TP, PF-LDH/ADA, and PF-LDH/TP provided the best predictive capacity, with an overall accuracy of 84.8% (95/112). TPE, tuberculous pleural effusion; MPE, malignant pleural effusion; CPPE, complicated parapneumonic effusion; UPPE, uncomplicated parapneumonic effusion; CTDs, connective tissue diseases. ADA, pleural fluid adenosine deaminase; PF-LDH, pleural fluid lactate dehydrogenase; S-Alb, serum albumin; S-LDH, serum lactate dehydrogenase; TP, pleural fluid total protein