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. 2021 Mar 20;9:46. doi: 10.1186/s40478-021-01136-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Age dependent accumulation of human α-syn deposits within the liver of the A30P transgenic mouse model. A–C Identification of human α-syn deposits (red) in young (3 months) liver tissue sections of the A30P mice located within the portal tracts and D–F, rosette-like structures within the liver parenchyma. Insert within panel A shows the deposition of α-syn at 3 months of age immune-stained with pS129 antibodies (green). G–I Aged A30P liver tissue sections (18 months) showing the progressive accumulation of α-syn deposits within the portal tracts and J–L, liver parenchyma. Insert within panel G shows the deposition of α-syn at 18 months of age immune-stained with pS129 antibodies (green). All liver tissue sections were counterstained with DAPI (blue). Bars = 20 µm