Table 3.
Studies about quantitative methods of elastography
| Study | Study type | Method | Pathological result | Number of LNs | Cut-off | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) |
|---|---|---|---|---|---|---|---|---|---|---|
| He et al. [51] | Retrospective | SR | LNs (12 Scc, 11 Adc, 9 SCLC, 10 low differentiation cancer, 26 benign) | 68 | 32.07 | 88.1 | 80.8 | 88.1 | 80.8 | 85.3 |
| Rozman et al.[59] | Prospective | SR | Patients (14 Adc, 8 Scc, 3 SCLC and 2 NSCLC, 2 post-tuberculotic changes, 2 pneumonia/lung abscesses, 1 sarcoidosis and 1 infectious mononucleosis) | 80 | 8 | 88.24 | 84.78 | 81.08 | 90.7 | 86.25 |
| Korrungruang and Boonsarngsuk [48] | Prospective | SR | LNs (11 SCLC, 68 NSCLC, 15 metastasis, 2 lymphoma, 15 TB, 1 histoplasmosis, 1 silicosis, 7 reactive lymph node) | 120 | 15.3 | 87.5 | 79.2 | 94.4 | 61.3 | \ |
| Verhoeven et al. [56] | Retrospective | SR | LNs (75 benign, 19 adenocarcinoma, 15 squamous cell carcinoma, 1 NSCLC NOS, 5 small cell lung carcinoma, 3 large cell neuroendocrine carcinoma, 2 invasive ductal carcinoma) | 120 | 1.67 | 47 | 84 | 64 | 72 | 70 |
| Trosini-Désert et al.[58] | Prospective | SR | LNs (56 nonmalignant, 42 malignant) | 98 | 5.3 | 86 | 73 | 71 | 87 | \ |
| Nakajima et al. [62] | Retrospective | SAR | Patients (14 lung cancer, 6 extrathoracic malignancies, 1 benign adenopathy) | 49 | 0.311 | 81 | 85 | \ | \ | \ |
| Abedini et al. [61] | Prospective | SAR | Patients (10 sarcoidosis, 1 TB, 5 reactive, 2 LC,5 Adc, 1 metastatic carcinoma, 1NSCLC, 1 mucinous cystadenoma) | 69 | 0.36 | 80 | 85 | 80 | 85 | 83 |
| Mao et al. [64] | Retrospective | SAR | LNs (12 Adc, 5 Scc, 4 NSCLC, 13 SCLC, 1 lymphoma, 7 TB, 12 sarcoidosis, 14 nonspecific lymphadenitis) | 68 | 0.48 | 82.86 | 81.82 | 82.86 | 81.82 | 82.35 |
| Ma et al.[63] | Retrospective | BCP | LNs (17 Adc, 2 Scc, 9 SCLC, 9 poorly differentiated carcinoma, 2 intestinal metastasized lung carcinoma, 22 normal lymphatic tissue, 14 inflammatory exudation, 2 bacterial infection, 2 noncaseating granulomas sarcoidosis) | 79 | 36.7% | 92.3 | 67.5 | \ | \ | 78.5 |
| Trosini-Désert et al. [58] | Prospective | Strain histogram | LNs (18 Adc, 9 Scc, 7 NSCLC, 5 SCLC, 1 lymphoma, 2 breast cancer metastases, 1 pancreatic cancer metastases, 1 hepatocellular carcinoma metastases, 61 normal lymph node tissue, 2 tuberculosis, 3 sarcoidosis) | 110 | 74.3 | 73 | 92 | 86 | 84 | \ |
| Verhoeven et al. [56] | Retrospective | Strain histogram | LNs (75 benign, 19 Adc, 15 Scc, 1 NSCLC-NOS, 5 small cell lung carcinoma, 3 large cell neuroendocrine carcinoma, 2 invasive ductal carcinoma) | 120 | 78 | 93 | 75 | 69 | 95 | 82 |
| Sun et al.[54] | Retrospective | Mean gray value | LNs (12 Adc, 5 Scc, 4 NSCLC-NOS, 13 SCLC, 1 lymphoma, 7 TB, 12 sarcoidosis, 14 nonspecific lymphadenitis) | 68 | 192.32 | 91.43 | 72.73 | 78.05 | 88.89 | 82.35 |
| Mao et al.[64] | Retrospective | Mean hue value | LNs (12 Adc, 5 Scc, 4 NSCLC, 13 SCLC, 1 lymphoma, 7 TB, 12 sarcoidosis, 14 nonspecific lymphadenitis) | 68 | 126.28 | 85.71 | 75.76 | 78.95 | 83.33 | 80.88 |
Adc: Adenocarcinoma; Scc: Squamous cell carcinoma; SCLC: Small cell lung cancer; NSCLC: Non-SCLC; TB: Tuberculosis; NSCLC-NOS: NSCLC not otherwise specific; EBUS: Endobronchial ultrasound; SR: Strain ratio; SAR: Stiff area ratio; BCP: Blue color proportion; LNs: Lymph nodes