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. 2021 Mar 17;9:e11067. doi: 10.7717/peerj.11067

Figure 5. Anti-tumor activities of dinaciclib and gemcitabine in CCA cell lines.

Figure 5

(A) The expression levels of CDC20 mRNA in patient CCA tissues (red) and normal counterparts (grey) retrieved from TCGA. (B) Representative western blots of CDC20 in four CCA cell lines and (C) the semi-quantitative analysis. Anti-tumor activities of dinaciclib and gemcitabine in CCA cell lines were determined in (D–E) 2D and (F–G) 3D cell culture model. (H) The representative multicellular tumor spheroids of KKU-213A after 72 h incubation with or without the indicated drugs. *P < 0.05.