Table 2.
Patient management strategies and outcomes in the included studies
| Study | Invasive Mechanical Ventilation | NMBA | Prone Positioning | Pulmonary vasodilator | ECMO | Death | Still in ICU | Discharged from ICU |
|---|---|---|---|---|---|---|---|---|
| Schmidt [17] |
3376/4643 (72%) |
1966/2224 (88%) |
1556/2223 (70%) |
425/2224 (19%) |
235/2153 (11%) |
1298/4244 (31%) | ||
| Gupta [21] | 1859/2215 (84%) | 909/1859 (49%) | 852/1859 (46%) | 212/1859 (11%) | 61/1859 (3.3%) | 875/2215 (39.5%) | ||
| Grasselli [22] | 2929/3355 (87%) | 64/3857 (1.7%) | 1769/3988 (44%) | 91/3988 (2.3%) | 2049/3988 (51%) | |||
| Ferrando [19] | 742/742 (100%) | 536/742 (72%) | 564/735 (77%) | 21/738 (2.8%) | 241/742 (32%) | 100 (13%) | 401/742 (54%) | |
| Botta [23] |
553/553 (100%) |
183/487 (38%) | 283/530 (53%) | 2/553 (< 1%) | 203/530 (38%) | |||
| Grasselli [18] | 301/301 (100%) |
93/261 (35.6%) |
||||||
| Schenck [26] | 267/267 (100%) | 161/267 (60%) | 108/267 (40%) | 49/267 (18%) | 140/267 (52%) | |||
| Cummings [20] | 203/257 (79%) | 51/203 (25%) | 35/203 (17%) | 22/203 (11%) | 6/203 (3%) | 101/257 (39%) | ||
| Roedl [24] | 167/223 (75%) | 37/167 (22%) | 108/167 (64%) | 19/167 (11%) | 20/223 (9%) | 78/223 (35%) | ||
| Auld [25] | 165/217 (76%) | 22/165 (13%) | 4/165 (2%) | 62/217 (29%) | 8/217 (4%) | 147/217 (68%) | ||
| Mitra [8] | 74/117 (63%) | 50/74 (68%) | 21/74 (28%) | 8/74 (11%) | 3/74 (4%) | 18/117 (15%) | 12/117 (10%) | 87/117 (74%) |
| Pandya [35] | 75/75 (100%) | 37/75 (49%) | ||||||
| Cavayas [41] |
43/75 (56%) |
16/43 (37%) | 11/43 (26%) | 15/43 (35%) | 1 (2%) | 17/75 (23%) | 58/75 (77%) | |
| Zangrillo [36] | 73/73 (100%) | 53/70 (76%) | 55/72 (76%) | 5/73 (7%) | 17/73 (23%) | 33/73 (45%) | 23/73 (32%) | |
| Ziehr [28] | 66/66 (100%) | 28/66 (42%) | 31/66 (47%) | 18/66 (27%) | 3/66 (5%) | 11/66 (17%) | 5/66 (8%) | 50/66 (76%) |
| Sinha [27] | 39/39 (100%) | 17/39 (44%) | ||||||
| Laverdure [37] | 36/36 (100%) | 29/36 (81%) | 9/39 (25%) | 7 (19%) | 4/36 (11%) | 7/36 (19%) | 25/36 (69%) | |
| Bhatraju [29] | 18/24 (75%) | 7/18 (39%) | 5/18 (28%) | 5/18 (28%) | 0 | 12/24 (50%) | ||
| Pedersen [38] | 17/17 (100%) | 5/17 (29%) | 0 | 7/17 (41%) | 6/17 (35%) | 4/17 (24%) | ||
| Liu X [40] | 8/8 (100%) | 0/8 | 3/8 (37%) | 5/8 (63%) | ||||
| LUNGSAFE [50] | 21.7% | 7.9% | 7.7% | 3.2% | 35.3% |
Data are number of patients (% of the subgroup). NMBA, neuromuscular blocking agent; ECMO, extracorporeal membrane oxygenation; ICU intensive care unit