. 2021 Mar 20;52:49. doi: 10.1186/s13567-021-00918-w

Table 4.

Summary of the experimental conditions of S. suis co-infection with bacterial pathogens using in vivo models

S. suis coinfection pathogen	Age of animals infected with 1st bacterial spp.	Age of animals infected with 2nd bacterial spp.	1st bacteria route of infection	2nd bacteria route of infection	1st bacteria and dose	2nd bacteria and dose	Conclusions	Refs.
Aerococcus viridans	Five-week-old BABL/c mice	Five-week-old BABL/c mice	IP	IP	10³ – 10⁸ CFU S. suis « novel serotype» (no further details on the strain)	10³ – 10⁸ CFU A. viridians	↑ Mortality	[137]
Bordetella bronchiseptica	Five-day old germ-free piglets	Seven-day-old germ-free piglets	IN	IN	0.5 × 10⁷ CFU B. bronchiseptica	0.7 × 10⁶ CFU; serotype 2, ST1, different phenotypes	↑ Clinical signs	[141]

S. suis coinfection pathogen

Age of animals infected with 1st bacterial spp.

Age of animals infected with 2nd bacterial spp.

1st bacteria route of infection

2nd bacteria route of infection

1st bacteria and dose

2nd bacteria and dose

Conclusions

Refs.

Aerococcus viridans

Five-week-old BABL/c mice

10³ – 10⁸ CFU

S. suis « novel serotype» (no further details on the strain)

10³ – 10⁸ CFU

A. viridians

↑ Mortality

Bordetella bronchiseptica

Five-day old germ-free piglets

Seven-day-old germ-free piglets

0.5 × 10⁷ CFU

B. bronchiseptica

0.7 × 10⁶ CFU; serotype 2, ST1, different phenotypes

↑ Clinical signs

IP: intraperitoneal injection; IN: intranasal inoculation; CFU: colony-forming units; ST: sequence type.