Skip to main content
. Author manuscript; available in PMC: 2021 Mar 20.
Published in final edited form as: Annu Rev Pathol. 2019 Sep 3;15:71–95. doi: 10.1146/annurev-pathmechdis-012419-032654

Table 1.

Cancer-associated genes reported in endometriosis cases

Gene symbol Gene name Localization Function Role in cancer
KRAS Kirsten rat sarcoma viral oncogene homolog Chromosome 12: p12.1; plasma membrane GTPase activity, positive control of cell growth and division, cell response to stimuli, cellular metabolism, regulator of signal transduction Oncogene
ARID1A AT-rich interaction domain 1A (SWI-like) Chromosome 1: p35.3; nucleus ATP-dependent chromatin remodeling factor, DNA binding, transcription regulator, DNA damage response Tumor suppressor
PIK3CA Phosphatidylinositol- 4,5-bisphosphate 3-kinase, catalytic subunit alpha Chromosome 3: q26.3; cytosol AKT pathway activator; serine/threonine protein kinase; cell growth, proliferation, differentiation, motility, survival; intracellular trafficking Oncogene
PPP2R1A Protein phosphatase 2, regulatory subunit Aalpha Chromosome 19: q13.41; cytosol, mitochondria, nucleus Serine/threonine protein phosphatase, negative control of cell growth and division, regulation of gene transcription Oncogene or tumor suppressor, depending on mutation type