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. 2021 Mar 16;14:907–916. doi: 10.2147/JIR.S301971

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© 2021 Luo et al.

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Adiponectin attenuated TGF-β1 mediated expression of collagen I and FN, and upregulates TGF-β1 suppressed MMP-1 expression in KFs by AMPK signaling pathway. KFs and NFs were preincubated with Compound C (10 µM, an AMPK inhibitor), or LY294002 (10 µM, a PI3K inhibitor) or without inhibitors for 24 h. After stimulation with or without adiponectin (APN, 5 µg/mL) in the presence of TGF-β1 (10 ng/mL) for 24 h, the supernatant concentration and mRNA levels of type I collagen (A and D), FN (B and E), and MMP-1 (C and F) in KFs and NFs were examined by ELISA and qPCR, respectively. Data represent at least three independent experiments. *P<0.05 versus the control group, **P<0.01 versus the control group; ^#P<0.05 versus the TGF-β1 group, ^##P<0.01 versus the TGF-β1 group; ^&P<0.05 versus the TGF-β1+adiponectin group, ^&&P<0.01 versus the TGF-β1+adiponectin group. The results are shown as means±SE.