Skip to main content
. Author manuscript; available in PMC: 2021 Aug 18.
Published in final edited form as: Oncogene. 2021 Feb 18;40(11):2035–2050. doi: 10.1038/s41388-021-01687-8

Fig. 7. Induction of apoptosis, ER stress, and lymphocyte infiltration in advanced adenomas from NSAID-treated patients.

Fig. 7

(A), (B) Advanced adenomas from 9 NSAID-treated patients and 7 untreated patients were analyzed by immunostaining for (A) active caspase 8 and (B) pEIF2α (S51). Left panels: representative staining pictures with arrows indicating example positive signals. Scale bars: 25 µm. Right panels: quantification of positive signals. Means + SD are shown. *** P < 0.001. (C) Advanced adenomas from 16 NSAID-treated and 14 untreated patients were analyzed for CD8 by immunostaining. Left panels: representative staining pictures. Scale bars: 200 µm. Right panel: quantification of positive signals. Means + SEM are shown. (D) Proposed mechanism of NSAID-induced immunogenic cell death in APC-deficient normal epithelial cells.