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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Adv Drug Deliv Rev. 2021 Jan 9;170:142–199. doi: 10.1016/j.addr.2021.01.005

Fig.12.

Fig.12.

(a) Schematic illustration of the bioinspired MNC@M-ST/AP fabrication and its application for anti-atherosclerosis by integrating multiple-targeting. (b) In vivo T2-weighted MRI images of the aorta areas, PBS injected mice were used as control. (c) The signal to notice ratio (SNR) values of different MNC-based nanoparticles in aorta areas determined by cine flash MR imaging system. (d) Photographs of excised Oil red O-stained aortas at the time of sacrifice and the corresponding quantitative analyses of plaque areas (top); photographs of Oil red O-stained cryosections of the aortic valves and the corresponding quantitative analyses of plaque areas (bottom). (e) ELISA assays for the expression levels of MCP-1, IL-6, TNF-α, and MMP-10 in the plaque areas of mice with different treatments. Reproduced with permission from Ref. [349]. Copyright 2019, Elsevier.