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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Adv Drug Deliv Rev. 2021 Jan 9;170:142–199. doi: 10.1016/j.addr.2021.01.005

Fig.2.

Fig.2.

(a) Uptake efficacy of cyanine (Cy)7-HA-NPs in aortic, splenic, and bone marrow macrophages measured by flow cytometry. (b) Representative images of aortic roots from mice that received either buffer (control), HA-NPs, or free HA during a 12-week high-fat feeding period. (c) Selectivity of HA-NPs toward plaque-associated macrophages expressed as the percentage of HANP-positive area that colocalizes with CD68-positive macrophage area. (d) Comparison of the endothelial adherens junction architecture and HA-NP uptake efficacy in atherosclerotic lesions of mice under 6 weeks and 12 weeks of HFD: the upper chart displays low and high resolution of the mean VEC continuity determined in the plaque, and the lower chart shows the HA-NP uptake efficacy expressed as the fraction of HA-NP-positive plaque area and (e-f) associated quantification of mean junction continuity (e) and HA NP accumulation (f). (g) Confocal microscopy images of VEC-stained endothelial junctions (red) and HA-NPs (cyan blue) at the surface of an atherosclerotic plaque. Reproduced with permission from Ref. [29, 30]. Copyright 2017 and 2020, American Chemical Society.