Table 3.

LD patients identified at baseline by the 10 proteins as described in Figures 1 and 2. Each of the 10 proteins identifies patients with various sensitivity at the indicated cutoff level of fold change compared to average of healthy controls as shown in Figure 1B, with low false positive rates (2.5–7.5%). A combination of 10 proteins identified all 40 LD patients at the indicated cutoff protein levels. In the righthand column, the number of proteins with serum level exceeding the cutoff fold change is listed for every LD patient.

Patient ID	AFM	ALDOB	APOA4	C9	CRP	CST6	FBP1	ITIH2	PGLYRP2	S100A9	# of “+” proteins
	< 0.55*	> 2.2	< 0.46	> 1.45	> 2.7	< 0.58	> 1.6	< 0.60	< 0.58	>1.8
LD01				+						+	2
LD02				+			+				2
LD03		+	+	+	+		+	+		+	7
LD04		+	+			+	+	+			5
LD05				+	+					+	3
LD06		+	+	+		+	+				5
LD07				+	+	+		+			4
LD08					+	+				+	3
LD09				+	+	+					3
LD10			+	+	+						3
LD11			+		+						2
LD12					+	+			+		3
LD13				+	+	+					3
LD14				+	+						2
LD15	+			+						+	3
LD16			+							+	2
LD17	+							+	+		3
LD18			+		+						2
LD19					+						1
LD20					+	+					2
LD21			+			+		+	+		4
LD22					+	+					2
LD23				+	+		+				3
LD24	+				+						2
LD25	+	+		+		+	+			+	6
LD26					+						1
LD27					+	+		+	+	+	5
LD28	+		+		+	+		+	+		6
LD29			+	+	+			+	+		5
LD30			+	+	+	+		+			5
LD31			+	+	+	+	+				5
LD32		+		+	+		+			+	5
LD33		+	+	+	+		+			+	6
LD34		+		+	+		+			+	5
LD35		+	+	+		+	+				5
LD36			+		+	+					3
LD37	+			+		+		+	+		5
LD38	+	+	+	+		+	+		+		7
LD39	+	+	+	+	+	+	+	+	+		9
LD40	+		+			+		+	+		5
# LD patient	9	11	18	23	31	21	13	15	13	11
% LD patient	22.5%	27.5%	45.0%	57.5%	77.5%	52.5%	32.5%	37.5%	32.5%	27.5%

^*:the cut-off fold change of serum concentration compared to average of healthy controls.

+: patient identified by each of the 10 proteins with relative serum concentrations beyond the cut-off protein values.