. Author manuscript; available in PMC: 2021 Jul 1.

Published in final edited form as: Cancer Prev Res (Phila). 2020 Sep 21;14(1):31–40. doi: 10.1158/1940-6207.CAPR-20-0368

Table 1.

Effect of p53^172H/H and MB^−/− genotypes on thymus by RNA-Seq analysis

KEGG pathway Term	p53^172H/H		MB^−/− p53^172H/H
	p53^+/+		MB^+/+ p53^172H/H
	Up-regulated		Down-regulated
	Count	P	Count	P
Carbon metabolism	42	1.30E-05	16	9.70E-03
Purine metabolism	55	1.10E-04	21	1.50E-02
Ribosome biogenesis	33	1.60E-10	12	2.10E-02
Calcium signaling	50	2.70E-03	20	3.00E-02
Calcium signaling	12	1.60E-04	5	3.40E-02

Myoglobin ablation down-regulates the metabolic pathways induced by p53^172H/H genotype. RNA-Seq was performed using thymus of 10 wk old male mice of the indicated genotypes, and KEGG pathway analysis was performed with DAVID Bioinformatics Resources 6.8 (n = 3–6). The pathways significantly induced in p53^172H/H vs. p53^+/+ state while being reversed by MB^−/− state in the p53^172H/H background are shown.