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. Author manuscript; available in PMC: 2022 May 12.
Published in final edited form as: Chem Rev. 2020 Sep 21;121(9):5098–5123. doi: 10.1021/acs.chemrev.0c00587

Figure 6: Model for retrograde phospholipid transport by the Mla system.

Figure 6:

Phospholipids that are mislocalized to the outer leaflet of the outer membrane first interact with the MlaA-OmpC complex and transverse the bilayer through a central pore in MlaA. Next, the phospholipid molecule is transferred to the periplasmic chaperone MlaC. MlaC moves across the periplasm and docks onto the IM MlaFEDB complex at the inner membrane. The phospholipid molecule is moved through this complex back into the inner membrane in an ATP-dependent fashion. It is unknown whether the phospholipid is placed in the inner or outer leaflet of the inner membrane. To avoid cluttering, the transmembrane domain of only one of the six MlaD monomers is depicted.