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. 2019 Dec 24;271(3):447–456. doi: 10.1007/s00406-019-01092-z

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© The Author(s) 2019

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Schedule of CSDS and FACS analysis. a The schedule of chronic social defeat stress (CSDS) model, social interaction test, and collection of spleen. CSDS was performed for 10 days (day 1- day 10). On day 11, the social interaction test was performed to separate CSDS-susceptible mice and CSDS-resilient mice. Control (no CSDS) mice were used as control group. On day 12, spleen from the three groups was collected. b Representative picture of spleen from control (no CSDS) mice, CSDS-susceptible mice, and CSDS-resilient mice. Spleen weight of CSDS-susceptible mice was significantly higher than that of control mice and CSDS-resilient mice (one-way ANOVA, F_2,21 = 437.136, P < 0.001). c Total cell number of spleen (one-way ANOVA, F_2,21 = 6.616, P = 0.006). d T cells: The number of TCR⁺ cells in the spleen (one-way ANOVA, F_2,21 = 0.032, P = 0.968). e B cells: The number of B220⁺ in the spleen (one-way ANOVA, F_2,21 = 1.429, P = 0.262). f Granulocyte: The number of Gr1⁺ cells in the spleen (one-way ANOVA, F_2,21 = 14.958, P < 0.001). g A positive correlation (r = 0.845, P < 0.001) between Gr1⁺ cells (for granulocytes) and spleen weight among three groups. Data are shown as mean ± SEM. (n = 8). **P < 0.01, ***P < 0.001 ANOVA analysis of variance, B220 B cells, Gr1 granulocyte receptor 1, CD11b a marker of macrophages, N.S. not significant, TCR T cell receptor