Table 1.
Demographic information of participants who were included in the MRI analysis.
| Cohort 1a | Cohort 2b | ||
|---|---|---|---|
| Baseline | n (females) | 55 (26) | 59 (30) |
| Mean age (SD) |
9.61 (0.34) [8.85–10.29] |
12.62 (0.32) [11.86–13.03] |
|
| Puberty status (SD) |
1.4 (0.60) [1–3] |
2.81 (0.99) [1–4] |
|
| Total segmented volumec (SD) |
1179287 (107546.2) [947801–1464491] |
1191869 (108286.7) [975723–1420689] |
|
| IQ (HAWIK-GAI) |
119.49 (13.45) [92–148] |
117.92 (11.64) [87–146] |
|
| 12 months | n (females) | 48 (22) | 46 (21) |
| Mean age (SD) |
10.81 (0.38) [9.93–11.39] |
13.85 (0.43) [12.94–14.86] |
|
| Puberty status (SD) |
1.75 (0.76) [1–3] |
3.28 (0.89) [1–5] |
|
| Total segmented volumec (SD) |
1196196 (106075.1) [938994–1439917] |
1191269 (103432.8) [986087–1414269] |
|
| Days since baseline (SD) |
413.53 (65.61) [279–579] |
415.33 (62.91) [333–611] |
|
| 24 months | n (females) | 41 (17) | 39 (17) |
| Mean age (SD) |
11.80 (0.38) [10.97–12.50] |
14.86 (0.41) [14.21–16.01] |
|
| Puberty status (SD) |
2.10 (0.80) [1–3] |
3.51 (0.85) [1–5] |
|
| Total segmented volumec (SD) |
1187069 (99999.5) [988972–1393745] |
1193478 (113822.7) [988529–462798] |
|
| Days since 12 months (SD |
342.90 (75.70) [210–676] |
358.54 (97.06) [214–737] |
SD standard deviation; range: in square brackets; IQ intelligence quotient; HAWIK-GAI Hamburg-Wechsler Intelligenztest für Kinder-General Ability Index.
aCohort 1, 9–10 years old at baseline
bCohort 2, 12–13 years old at baseline
cTotal segmented volume presented in mm3