Table 4:
Adjusted Pooled Odds Ratios for the Association Between Offspring Sex and Mucinous Epithelial Ovarian Cancer Stratified by History of Estrogenic Conditions Among Parous Women with Only Singleton Births in the Ovarian Cancer Association Consortium (Australia, Europe, and North America), 1989–20101
| Age at Menarche <13 years | Age at Menarche >13 years | |||||
|---|---|---|---|---|---|---|
| Controls N(%) | Cases N(%) | Adjusted OR (95% Cl) | Controls N(%) | Cases N(%) | Adjusted OR (95% Cl) | |
| Gave birth to a boy | ||||||
| Never | 916(22.52) | 56(18.24) | ref | 1032 (20.72) | 91 (21.46) | ref |
| Ever | 3152 (77.48) | 251 (81.76) | 1.71 (1.23, 2.38) | 3949 (79.28) | 333 (78.54) | 0.99 (0.76, 1.30) |
| P for interaction | 0.02 | |||||
| Gave birth to all boys | ||||||
| Not all boys | 3124 (76.79) | 205 (66.78) | ref | 3913 (78.56) | 314 (74.06) | ref |
| All boys | 944 (23.21) | 102 (33.22) | 1.55 (1.18, 2.04) | 1068 (21.44) | 110 (25.94) | 1.08 (0.83, 1.40) |
| P for interaction | 0.08 | |||||
| No. of boys | ||||||
| No boy | 916(22.52) | 56(18.24) | ref | 1032 (20.72) | 91 (21.46) | ref |
| 1 boy | 1663 (40.88) | 132 (43.00) | 1.54(1.09, 2.18) | 2137 (42.90) | 176 (41.51) | 0.94 (0.71, 1.24) |
| 2 boys | 1010 (24.83) | 86 (28.01) | 2.34(1.55, 3.53) | 1222 (24.53) | 105 (24.76) | 1.16 (0.82, 1.63) |
| 3 or more boys | 479 (11.77) | 33 (10.75) | 2.24 (1.27, 3.98) | 590(11.85) | 52 (12.26) | 1.20 (0.75, 1.93) |
| P for trend | 0.002 | 0.32 | ||||
| P for interaction | 0.10 | |||||
| Number of boys2 | 1919 (100.00) | 132 (100.00) | 1.04 (0.92, 1.18) | 4981 (100.00) | 424 (100.00) | 1.01 (0.90, 1.12) |
| P for interaction | 0.51 | |||||
| Number of girls2 | 1919 (100.00) | 132 (100.00) | 0.79 (0.69, 0.91) | 4981 (100.00) | 424 (100.00) | 0.94 (0.84, 1.05) |
| P for interaction | 0.02 | |||||
| Fraction of births that were boys, 25% increase3 | 1919 (100.00) | 132 (100.00) | 1.18(1.09, 1.28) | 4981 (100.00) | 424 (100.00) | 1.03 (0.95, 1.11) |
| P for interaction | 0.01 | |||||
1
Adjusted for study sites, age at diagnosis/reference date (continous), race (Black, White, Asian, Other), duration of oral contraceptive use (never, less than 1 years, 1–4 years, 5–9 years, and more than 10 years) and number of full-term pregnancies (1, 2, 3, 4, 5+)
2
Adjsuted for each other
3
Models adjust for total number of full term pregnancies as a continous variable