Table 5:
Adjusted Pooled Odds Ratios for the Association Between Offspring Sex and Endometrioid Epithelial Ovarian Cancer Stratified by History of Androgenic Conditions Among Parous Women with Only Singleton Births in the Ovarian Cancer Association Consortium (Australia, Europe, and North America), 1989–20101
| History of Acne or Hirsutism or PCOS | No history of Acne or Hirsutism or PCOS | |||||
|---|---|---|---|---|---|---|
| Controls N(%) | Cases N(%) | Adjusted OR (95% Cl) | Controls N(%) | Cases N(%) | Adjusted OR (95% Cl) | |
| Gave birth to a boy | ||||||
| Never | 253 (21.9) | 28 (34.1) | ref | 832 (21.3) | 48(18.8) | ref |
| Ever | 904 (78.1) | 54 (65.9) | 0.49 (0.28, 0.83) | 3074 (78.7) | 207 (81.2) | 1.64(1.14, 2.34) |
| P for interaction | 0.003 | |||||
| Gave birth to all boys | ||||||
| Not all boys | 894 (77.3) | 65 (79.3) | ref | 3075 (78.7) | 197 (77.3) | ref |
| All boys | 263 (22.7) | 17 (20.7) | 0.88 (0.49, 1.59) | 831 (21.3) | 58 (22.7) | 0.93 (0.67, 1.28) |
| P for interaction | 0.56 | |||||
| No. of boys | ||||||
| No boy | 253 (21.9) | 28 (34.1) | ref | 832 (21.3) | 48(18.8) | ref |
| 1 boy | 492 (42.5) | 27 (32.9) | 0.47 (0.27, 0.85) | 1606 (41.1) | 127 (49.8) | 1.69 (1.18, 2.44) |
| 2 boys | 275 (23.8) | 18(22.0) | 0.52 (0.26, 1.06) | 1004 (25.7) | 64 (25.1) | 1.59 (1.02, 2.49) |
| 3 or more boys | 137 (11.8) | 9 (11.0) | 0.47 (0.16, 1.67) | 464(11.9) | 16(6.3) | 0.78 (0.39, 1.56) |
| P for trend | 0.21 | 0.47 | ||||
| P for interaction | 0.007 | |||||
| Number of boys2 | 1157 (100.0) | 82 (100.0) | 0.77 (0.60, 0.99) | 3906 (100.0) | 255 (100.0) | 0.82 (0.71, 0.95) |
| P for interaction | 0.44 | |||||
| Number of girls2 | 1157 (100.0) | 82 (100.0) | 1.02 (0.81, 1.30) | 3906 (100.0) | 255 (100.0) | 0.80 (0.69, 0.93) |
| P for interaction | 0.03 | |||||
| Fraction of births that were boys, 25% increase3 | 1157 (100.0) | 82 (100.0) | 0.85 (0.72, 1.00) | 3906 (100.0) | 255 (100.0) | 1.06 (0.96, 1.15) |
| P for interaction | 0.03 | |||||
1
Adjusted for study sites, age at diagnosis/reference date (continous), race (Black, White, Asian, Other), duration of oral contraceptive use (never, less than 1 years, 1–4 years, 5–9 years, and more than 10 years) and number of full-term pregnancies (1, 2, 3, 4, 5+)
2
Adjsuted for each other
3
Models adjust for total number of full term pregnancies as a continous variable