Table 1.
Roles and pathways of chemokines and their receptors in ALL
Pathways | Roles | References | |
---|---|---|---|
CXCL12/CXCR4 | Myc | Proliferation | [16] |
Src and ABL1/RhoGDI2/RhoA and RhoC | Migration | [49, 50] | |
P38MAPK | Migration, homing | [40, 51] | |
RAC1 | Migration | [52, 53] | |
ERK1/2 | Infiltration, survival | [55] | |
PI3K/Akt | Survival | [60] | |
CCL25/CCR9 | RhoA-Rock-MLC and ezrin | Infiltration | [69, 70] |
PI3K/Akt-RhoA | Infiltration | [71] | |
P-gp/ERM/F-actin | Drug resistance | [75] | |
CXCL10/CXCR3 | Bcl-2/caspases | Survival | [80] |
MMP9 | Invasion | [82] | |
CCR5 | JAK/STAT3 | Proliferation, migration | [94] |