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. 2021 Mar 20;14:48. doi: 10.1186/s13045-021-01060-y

Table 1.

Roles and pathways of chemokines and their receptors in ALL

Pathways Roles References
CXCL12/CXCR4 Myc Proliferation [16]
Src and ABL1/RhoGDI2/RhoA and RhoC Migration [49, 50]
P38MAPK Migration, homing [40, 51]
RAC1 Migration [52, 53]
ERK1/2 Infiltration, survival [55]
PI3K/Akt Survival [60]
CCL25/CCR9 RhoA-Rock-MLC and ezrin Infiltration [69, 70]
PI3K/Akt-RhoA Infiltration [71]
P-gp/ERM/F-actin Drug resistance [75]
CXCL10/CXCR3 Bcl-2/caspases Survival [80]
MMP9 Invasion [82]
CCR5 JAK/STAT3 Proliferation, migration [94]