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. 2021 Mar 20;12:196. doi: 10.1186/s13287-021-02262-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Treatment of CS-EVs accelerates skin remodeling. a Histologic images of collagen remodeling by Masson trichrome staining. Scale bar, 150 μm. Boxed areas are shown at higher magnification. b Quantitative statistics of collagen fibers in each group. c Western blot analysis of COL1 and COL3 protein expression. d Histologic images of skin appendage regeneration by HE staining. Scale bar, 100 μm. e Protein expression of MMPs were detected by Western blotting in therapeutic skin tissue. f Gene expression level of MMPs in aging skin. g Gene expression level of TIMPs in aging skin with EVs or CS-EVs treatment was detected by RT-PCR. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01 vs Con; ^#P < 0.05 vs EVs. All experiments were performed in triplicate