Table 1.
Representative frequency distribution of FOK1 genotypes and alleles in Pemphigus vulgaris Patients and healthy controls
| FOK1 genotypes and alleles | Patients n=74 (%) | Controls n=130 (%) | Odds ratio (OR) | Confidence interval (CI)-95% | P |
|---|---|---|---|---|---|
| TT (Wild homozygous) | 3 (4.05%) | 4 (3.07%) | 1.331 | 0.29 to 6.116 | 0.975 |
| TC (Heterozygous carrier) | 28 (37.83%) | 86 (66.15%) | 0.311 | 0.172 to 0.564 | 0.0000* |
| CC (Mutant homozygous) | 43 (58.1%) | 40 (30.7%) | 3.121 | 1.724 to 5.649 | 0.0000* |
| T (Wild allele) | 34 (22.9%) | 94 (36.15%) | 0.527 | 0.333 to 0.833 | 0.008* |
| C (Mutant allele) | 114 (77.02%) | 166 (63.84%) | 1.899 | 1.2 to 3.005 | 0.008* |
| Carriage rate “T” | 31 (41.89%) | 90 (69.23%) | 0.3204 | 0.1770 to 0.5799 | 0.0002* |
| Carriage rate “C” | 71 (95.94%) | 126 (96.3%) | 0.7513 | 0.1635 to 3.4523 | 0.7133 |
*P≤0.05 was considered significant