TABLE 2.
Results From the Testing of Nickel Salts in Guinea Pig Skin Sensitization Tests
| Method | Test Substance | Induction* | Elicitation | Positive | Reference |
|---|---|---|---|---|---|
| Maximization test | NiSO4 | 1%/5% | 0.5% | 55% | 20 |
| Maximization test | NiSO4 | 2%/2% | Not given | 50% | 58 |
| Maximization test | NiSO4 | 0.25%/0.7% | 0.15% | 10% | 23 |
| Maximization test | NiSO4 | 5%/25% | 5% | 23% | 21 |
| Maximization test | NiCl2 | 1% | 0.2% | 53% | 59 |
| Maximization test | NiCl2 | 0.25%/2% | 0.1% | 10% | 23 |
| Optimization test | NiSO4 | 0.1%/5% | 0.5% | 35% | 18 |
| Draize test | NiSO4 | Not given | Not given | 0% | 20 |
| Draize test | NiCl2 | 0.375% | 10% | 0% | 23 |
| Freund's complete adjuvant test | NiSO4 | 25% | 5% | 31% | 21 |
| Draize test | NiSO4 | 0.375% | 10% | 0% | 23 |
| Open epicutaneous test | NiSO4 | 25% | 5% | 50% | 21 |
| TINA test | NiSO4 | 1%/1% | 5% | 24% | 22 |
*Injection induction or topical induction concentrations.