Table 2.

The summary results for grade 3 (or greater) adverse events.

Outcomes	No. of studies	RR and 95%CI	P	Heterogeneity (%)	P value for heterogeneity
Hemoglobin	8	1.24 (0.61–2.53)	.551	80.1	<.001
Leukocyte	7	2.17 (1.44–3.26)	<.001	90.3	<.001
Platelet	7	1.96 (1.24–3.09)	.004	42.1	.110
Granulocytes/Bands	3	3.16 (0.59–16.90)	.179	91.3	<.001
Lymphocytes	3	2.47 (0.89–6.88)	.082	82.8	.003
Neutropenia	4	0.96 (0.65–1.43)	.847	72.8	.012
ALT	2	1.63 (0.57–4.67)	.366	0.0	.492
Serum creatinine	2	0.97 (0.10–9.24)	.976	0.0	.320
Esophagitis	11	3.85 (2.39–6.21)	<.001	38.8	.090
Stomatitis	3	2.89 (0.89–9.38)	.077	0.0	.999
Nausea/vomiting	8	1.44 (1.05–1.97)	.024	31.7	.175
Diarrhea	2	0.66 (0.13–3.53)	.632	30.8	.229
Pulmonary	8	0.83 (0.49–1.42)	.501	38.0	.127
Infection	4	1.37 (0.78–2.42)	.269	0.0	.643
Neurotoxicity	5	0.75 (0.23–2.39)	.625	49.5	.095
Anorexia	2	1.01 (0.39–2.58)	.986	0.0	.518
Dyspnea	2	0.72 (0.35–1.47)	.361	0.0	.957
Heart	7	1.06 (0.54–2.11)	.857	0.0	.465
Sensory	2	3.08 (0.32–29.38)	.329	0.0	.927
Pain	2	1.29 (0.58–2.90)	.532	0.0	.823
Weight loss	3	0.98 (0.33–2.95)	.978	0.0	.407
Fatigue	3	1.54 (0.28–8.54)	.620	73.4	.023
Allergy	2	1.56 (0.19–12.50)	.677	0.0	.522
Fever	2	0.61 (0.08–4.90)	.642	0.0	.700