Table 1.

Characteristics of the studies included in the systematic review and meta-analysis.

Source	Sample size	Study Type	Country	Age, mean	Men(n,%)	Smoker (n,%)	Stroke type	CYP2C19∗ Alleles Reported	Follow-up	Quality Score
Dongmei Jia 2013	206	Cohort	China	66.5 ± 11.8	NR	NR	Cerebral embo lism and small vessel disease	CYP2C19∗1,∗2,∗3,∗17	6 mo	8
LiNa Qiu 2014	198	Cohort	China	67.47 ± 13.6	95, 45%	74, 35%	Acute ischemic stroke	CYP2C19∗2,∗3	6 mo	7
Yuting Zhao 2014	114	Cohort	China	65.97 ± 10.38	86, 75.44%	43, 37.7%	Ischemic stroke	CYP2C19∗1,∗2,∗3,∗17	12 mo	9
LiNa Qiu 2015	410	Cohort	China	64.8 ± 12.1	228, 55.6%	162, 39.5%	Acute ischemic stroke	CYP2C19∗1,∗2,∗3	31 mo	8
Chun Wang 2016	363	Cohort	China	69.96 ± 10.98	234, 62%	158, 42%	Atherothrombotic, Small artery disease	CYP2C19∗2,∗3	6 mo	9
Xingyang Yi 2016	550	Cohort	China	68.78 ± 12.26	112, 67.5%	212, 38.5%	Ischemic stroke	CYP2C19∗2	6 mo	8
Yingting Wang 2016	321	Cohort	China	62.0 ± 3.5	82, 25.5%	169, 52.6%	Ischemic stroke	CYP2C19∗2,∗3	12 mo	9
Hanqin Gao 2017	232	Cohort	China	60.09 ± 4.99	82, 71%	57, 49%	Symptomatic intracranial atherosclerotic stenosis	CYP2C19∗2,∗3	7 d	7
K. Fukuma 2017	195	Cohort	Japan	72.1	140, 58.6%	NR	Acute atherothrombotic stroke, TIA	CYP2C19∗1,∗2,∗3	3 mo	6
Chen 2018	189	Cohort	China	66.0 ± 10. 9	117, 60.9%	53, 27.6%	Ischemic stroke	CYP2C19∗2,∗3	12 mo	9
Jing Lin 2018	375	Cohort	China	70.2 ± 11.4	242,64.5%	158,42.1%	Ischemic stroke	CYP2C19∗2,∗3	7 mo	8
Xingyang Yi 2018	570	Cohort	China	70.9 ± 11.6	313, 55%	228, 40%	Ischemic stroke	CYP2C19∗2	10 d	7

CYP2C19 = cytochrome P450 2C19, TIA = transient ischemic attack.