Table 5.
Comparison of the studied variables between type 1 diabetes mellitus and its control group according to SNP rs1042522 and SNP rs1800795 genotypes of the TP53 and IL-6 genes.
| Variables | CC genotype SNP rs1042522 | CG + GG genotype SNP rs1042522 | GG genotype SNP rs1800795 | GC + CC genotype SNP rs1800795 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DM | Control | Sig. | DM | Control | Sig. | DM | Control | Sig. | DM | Control | Sig. | |
| BMI, kg/m2 | 21.96 (3.82) | 22.08 (2.73) | <0.001 | 26.49 (3.29) | 26.54 (1.85) | 0.067 | 21.56 (4.39) | 22.39 (3.45) | <0.001 | 27.77 (4.25) | 27.11 (2.12) | 0.011 |
| HBA1C, % | 8.52 (1.49) | 4.75 (0.34) | <0.001 | 8.21 (1.36) | 4.89 (0.32) | <0.001 | 8.77 (1.39) | 4.76 (0.32) | <0.001 | 8.33 (1.32) | 4.80 (0.41) | <0.001 |
| FBG, mg/dL | 174.27 (87.82) | 91.26 (6.38) | <0.001 | 191.43 (69.96) | 95.27 (5.52) | <0.001 | 189.88 (99.59) | 90 (6.53) | <0.001 | 195.94 (72.19) | 93.24 (6.19) | <0.001 |
| TC, mg/dL | 167.82 (36.96) | 176.29 (30.35) | 0.048 | 179 (45.87) | 191.63 (32.85) | 0.048 | 166.40 (31.94) | 177.64 (31.06) | 0.098 | 181.67 (47.97) | 184.84 (32.55) | 0.098 |
| Triglyceride, mg/dL | 121.91 (72.10) | 127.45 (46.79) | 0.015 | 125.91 (68.62) | 151.24 (61.30) | 0.15 | 107.29 (55.18) | 132.80 (59.36) | 0.003 | 131.23 (66.03) | 154.64 (58) | 0.003 |
| LDL-C, mg/dL | 87.23 (12.48) | 103 (14.77) | <0.001 | 103.70 (22.10) | 107.49 (15.23) | <0.001 | 86.57 (15.39) | 102.39 (13.87) | <0.001 | 104.44 (24.76) | 105.56 (16.24) | <0.001 |
| HDL-C, mg/dL | 50.18 (8.22) | 44.48 (5.37) | 0.002 | 41.57 (7.74) | 44.14 (8.35) | 0.002 | 48.40 (7.71) | 43.18 (6.24) | <0.001 | 41.15 (7.91) | 42.34 (7.82) | <0.001 |
| BUN, mg/dL | 31 (6.19) | 26.48 (5.75) | 0.025 | 29.09 (7.07) | 30.94 (7.35) | 0.025 | 27.29 (5.68) | 25.77 (5.34) | <0.001 | 31.31 (8.22) | 29.70 (5.02) | <0.001 |
| Creatinine, mg/dL | 0.86 (0.09) | 0.81 (0.13) | 0.018 | 0.86 (0.15) | 0.92 (0.18) | 0.018 | 0.8 (0.11) | 0.8 (0.15) | 0.014 | 0.92 (0.16) | 0.88 (0.12) | <0.001 |
DM – diabetes mellitus; BMI – body mass index; FBG – fasting blood glucose; TC – total cholesterol; LDL-C – low-density lipoprotein cholesterol; HDL-C – high-density lipoprotein cholesterol; BUN – blood urea nitrogen.