Table 6.
Comparison of the studied variables between type 2 diabetes mellitus and its control group according to SNP rs1042522 and SNP rs1800795 genotypes of the TP53 and IL-6 genes.
| Variables | CC genotype SNP rs1042522 | CG + GG genotype SNP rs1042522 | GG genotype SNP rs1800795 | GC + CC genotype SNP rs1800795 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DM | Control | Sig. | DM | Control | Sig. | DM | Control | Sig. | DM | Control | Sig. | |
| BMI, kg/m2 | 21.22 (4.30) | 22.03 (3.45) | <0.001 | 27.78 (3.99) | 27.05 (2.48) | <0.001 | 21.29 (3.82) | 21.38 (2.25) | 0.011 | 27.21 (3.5) | 26.52 (2.19) | <0.001 |
| HBA1C, % | 8.70 (1.39) | 4.68 (0.27) | <0.001 | 8.15 (1.43) | 4.84 (0.42) | <0.001 | 8.47 (1.46) | 4.63 (0.27) | <0.001 | 8.01 (1.5) | 4.94 (0.29) | <0.001 |
| FBG, mg/dL | 181.67 (86.17) | 90.37 (6.84) | <0.001 | 192.72 (66.02) | 93.11 (7.81) | <0.001 | 164.17 (60.11) | 92.36 (6.59) | <0.001 | 189.18 (61.50) | 95.42 (7.18) | <0.001 |
| TC, mg/dL | 169.78 (25.78) | 172.29 (31.03) | 0.076 | 175.96 (46.06) | 188.86 (34.11) | 0.076 | 173.17 (25.38) | 167.23 (28.91) | 0.002 | 172.04 (43.67) | 196.47 (33.39) | 0.002 |
| Triglyceride, mg/dL | 101.10 (40.14) | 127.97 (63.11) | <0.001 | 139.01 (86.67) | 157.43 (55.04) | <0.001 | 107.93 (49.37) | 117.59 (46.89) | 0.037 | 140.40 (96.05) | 153.51 (59.19) | 0.037 |
| LDL-C, mg/dL | 84.04 (16.15) | 99.09 (15.44) | <0.001 | 101.53 (25.39) | 105.80 (17.93) | <0.001 | 82.66 (14.59) | 98 (17.38) | <0.001 | 99.81 (24.44) | 107.98 (16.81) | <0.001 |
| HDL-C, mg/dL | 50.86 (7.74) | 42.11 (7) | <0.001 | 40.01 (7.62) | 44.77 (10.22) | <0.001 | 53.90 (6.93) | 43.32 (6.71) | <0.001 | 99.81 (24.44) | 46.76 (10.14) | <0.001 |
| BUN, mg/dL | 26.20 (6) | 24.26 (4.43) | <0.001 | 30.04 (7.05) | 29.66 (6.59) | <0.001 | 28.28 (7.44) | 24.36 (4.81) | 0.004 | 28.44 (5.44) | 31.07 (8.7) | 0.097 |
| Creatinine, mg/dL | 0.78 (0.11) | 0.79 (0.13) | <0.001 | 0.9 (0.16) | 0.88 (0.17) | <0.001 | 0.82 (0.12) | 0.77 (0.09) | 0.004 | 0.87 (0.15) | 0.92 (0.23) | 0.069 |
DM – diabetes mellitus; BMI – body mass index; FBG – fasting blood glucose; TC – total cholesterol; LDL-C – low-density lipoprotein cholesterol; HDL-C= high-density lipoprotein cholesterol; BUN= blood urea nitrogen.