Figure 5.
Associations of LPL (red), ANGPTL4 (blue), and ANGPTL3 (green) genotypes with (A) risk factors and (B) cardiometabolic endpoints. The detailed information on the source data (consortia or UK Biobank) used here is summarized in Supplementary material online, Table S3. For fasting insulin, as the instrument SNP was not available, proxy SNPs were used (rs3850634 for ANGPTL3 and rs11991231 for LPL, R 2 > 0.85 with the instrument SNP). However, no proxy with R 2 > 0.85 was found for ANGPTL4 rs116843064 and thus the result is missing from the figure. BMI, body mass index; WHRadjBMI, Waist-to-hip ratio adjusted for BMI. Closed symbols: P < 0.0002; open symbols: P ≥ 0.0002.