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. 2021 Mar 22;10(2):839–851. doi: 10.1007/s40121-021-00432-8

Table 3.

Therapies perceived as moderately or very effective in management of COVID-19-related symptoms and site of COVID-19-related patient care

All respondents Episodic carea Longitudinal careb p value
n (%) n (%) n (%)
Albuterol MDI (history of asthma) (n = 50) 47 (94.0) 18 (85.7) 29 (100.0) 0.07
Acetaminophen for fever (n = 54) 50 (92.6) 21 (87.5) 29 (96.7) 0.31
Non-sedating antihistamine (no history of allergic rhinitis) (n = 47) 33 (89.2) 13 (65.0) 20 (74.1) 0.54
Albuterol, nebulized (history of asthma) (n = 37) 31 (83.8) 9 (69.2) 22 (91.7) 0.16
Nasal steroid spray (history of allergic rhinitis) (n = 41) 34 (82.9) 16 (80.0) 18 (85.7) 0.70
Albuterol MDI (no history of asthma) (n = 49) 40 (81.6) 14 (70.0) 26 (89.7) 0.13
Nasal steroid spray (no history of allergic rhinitis) (n = 38) 31 (81.6) 14 (73.7) 17 (89.5) 0.41
NSAIDs myalgia, arthralgia (n = 25) 20 (80.0) 13 (81.3) 7 (77.8) 1.00
NSAIDs for headache (n = 30) 24 (80.0) 14 (82.4) 10 (76.9) 1.00
Non-sedating antihistamine (history allergic rhinitis) (n = 45) 36 (80.0) 17 (81.0) 19 (79.2) 1.00
Acetaminophen for myalgia, arthralgia (n = 50) 39 (78.0) 17 (77.3) 22 (78.6) 1.00
Codeine, hydrocodone for cough (n = 31) 24 (77.4) 10 (66.7) 14 (87.5) 0.22
NSAIDs for nasal or sinus pain (n = 22) 16 (72.7) 11 (73.3) 5 (71.4) 1.00
Decongestant for nasal congestion or postnasal drip (n = 40) 29 (72.5) 13 (68.4) 16 (76.2) 0.72
Benzonatate for cough (n = 52) 37 (71.2) 13 (59.1) 24 (80.0) 0.13
Sedating antihistamine for sleep (n = 31) 22 (71.0) 9 (56.3) 13 (86.7) 0.11
NSAIDs for fever (n = 24) 17 (70.8) 9 (60.0) 8 (88.9) 0.19
Hypnotic for sleep (n = 10) 7 (70.0) 4 (66.7) 3 (75.0) 1.00
Fioricet for headache (n = 13) 9 (69.2) 5 (71.4) 4 (66.7) 1.00
Acetaminophen for headache (n = 54) 37 (68.5) 16 (66.7) 21 (70.0) 1.00
Dextromethorphan for cough (n = 46) 31 (67.4) 12 (57.1) 19 (76.0) 0.22
Benzodiazepine for anxiety (n = 12) 8 (66.7) 3 (50.0) 5 (83.3) 0.55
Guaifenesin for cough (n = 47) 30 (63.8) 7 (38.9) 23 (79.3) 0.01*
Nasal saline lavage (n = 28) 17 (60.8) 6 (40.0) 11 (84.6) 0.02*
Sedating antihistamine for nasal congestion or postnasal drip (n = 29) 17 (58.6) 7 (53.8) 10 (62.5) 0.72
Nasal saline spray (n = 44) 23 (52.3) 9 (42.9) 14 (60.9) 0.37
Systemic steroids (n = 23) 12 (52.2) 5 (50.0) 7 (53.8) 1.00
Melatonin for sleep (n = 27) 14 (51.9) 4 (33.3) 10 (66.7) 0.13
Honey for cough (n = 33) 17 (51.5) 6 (50.0) 11 (52.4) 1.00
OTC lozenge for cough (n = 39) 20 (51.3) 7 (46.7) 13 (54.2) 0.75
Acetaminophen for nasal or sinus pain (n = 43) 21 (48.8) 10 (52.6) 11 (45.8) 0.76

COVID-19 coronavirus disease 2019, MDI metered-dose inhaler, NSAIDs non-steroidal anti-inflammatory drugs, OTC over-the-counter

aEpisodic care providers saw patients with COVID-19 for single visits by telemedicine or in-person

bLongitudinal care providers called patients regularly over time until symptom improvement

*Significant, p < 0.05