Table 2.

Comparison of M1 and M2 macrophage density across MRONJ staging and controls

	M1–M2 macrophage density
Variable	M1a median (IQR)	M2b median (IQR)	M1/M2 median (IQR)
MRONJ stage 1	10 (8–14)	18.5 (14–23)	0.56 (0.44–0.68)
MRONJ stage 2	25 (16–31)	9.5 (6–12)	2.11 (1.57–3.45)
MRONJ stage 3	21 (15–23)	11 (10–14)	1.55 (1.47–2)
Control–antiresorptive	3 (1–4)	9 (8–19)	0.2 (0.15–0.33)
Control–no antiresorptive	4 (3–4)	16 (11–16)	0.19 (0.16–0.32)
p-valuec	<0.001**	0.027*	<0.001**

^aCD68⁺/iNOS⁺ M1 macrophage density (cells/mm²).

^bCD68⁺/CD206⁺ M2 macrophage density (cells/mm²).

^cKruskal-Wallis H test.

^*p <0.05

^**p <0.01

MRONJ = Medication-Related Osteonecrosis of the Jaw; IQR= interquartile range.